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- Yuk-Ching Tse-Dinh Undergraduate Research Summary
Yuk-Ching Tse-Dinh Undergraduate Research Summary
Every bacterial pathogen has at least one type IA topoisomerase, providing a target for discovery of new antibiotics to combat multi-drug resistant infections, including MDR- and XDR-TB. The study of the structure and mechanism of bacterial topoisomerase I provide the basic foundation for translational application of this enzyme as a novel antibacterial target. Drug discovery research extends to anticancer drugs targeting human DNA topoisomerases. The control of DNA structure by DNA topoisomerases can affect stress response and genomic stability, with implications for bacterial pathogenesis and cancer.
List of peer-reviewed publications can be found here:
Recent publications/abstracts with undergraduate coauthors (*)
- *Yang J, Annamalai T, Cheng B, Banda S, Tyagi R, Tse-Dinh YC. Antimicrobial Susceptibility and SOS-dependent Increase in Mutation Frequency are Impacted by E. coli Topoisomerase I C-terminal Point Mutation. Antimicrob Agents Chemother 2015 Oct;59(10):6195-202.
- *Paz C, Annamalai T, Tse-Dinh YC. Screening for Novel Leads Towards Antibacterial Compounds Targeting Topoisomerase Ia, a New Target Found in All Bacteria, Annual Biomedical Research Conference for Minority Students, San Antonio, TX, September 2014.
- Annamalai T, *Parra C, Tse-Dinh YC. A novel assay to identify antibacterial compounds targeting bacterial topoisomerase I. SE Regional Meeting of the American Chemical Society, Atlanta, GA, November 2013.