Dr. Fenfei Leng publishes ground-breaking research on DNA structure and topology

FIU Professor of Biochemistry Fenfei Leng and co-workers recently discovered and confirmed the existence of DNA topological barriers that are able to block supercoil diffusion along the DNA double helix. This ground-breaking research on DNA structure and topology has been published in Proceedings of the National Academy of Sciences (PNAS): Fenfei Leng*, Bo Chen, David D. Dunlap “Dividing a supercoiled DNA molecule into two independent topological domains,” PNAS 2011 108 (50) 19973-19978. Click to read abstract.